Formation of gel and fibrous microstructures by 1-alkyne amphiphiles bearing L-serine headgroup in organic solvents

Ragunathan, Kaliappa G. ; Bhattacharya, Santanu (1995) Formation of gel and fibrous microstructures by 1-alkyne amphiphiles bearing L-serine headgroup in organic solvents Chemistry and Physics of Lipids, 77 (1). pp. 13-23. ISSN 0009-3084

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Official URL: http://dx.doi.org/10.1016/0009-3084(95)02450-W

Related URL: http://dx.doi.org/10.1016/0009-3084(95)02450-W

Abstract

The study of amphiphiles that form non-spheroidal, and other assemblies, upon solvation is the key to understanding the :relationship between molecular structure and supramolecular morphology. With this aim in mind, we have employed L -serine and L -histidine derivatives that are linked via amide bond to hydrophobic chain. L-Serine amphiphiles form gels in CHCl3, CH2Cl2 and CCI, Microscopic examinations of these gels reveal the coexistence of tubules, helical ribbons, and spheres. On the other hand, they produce only spherical structures and rods when dispersed in aqueous media (phosphate buffer). In contrast, amphiphiles based on the L-histidine group, neither formed any gel nor produced any microstructures in non-aqueous solvents like CHCl3, but produced spherical structures and helical rods in water. We also examined the effect of introducing 1-yne or 1-ene moieties into the hydrocarbon chain of such amphiphiles. These moieties, when present in the hydrophobic segment, do not perturb the supramolecular assembly features of the respective serine amphiphiles. Actually, 1-yne moiety, when present in the hydrophobic portion of the amphiphiles, gives characteristic UV-fine structures upon aggregation in water and might be used as a non-invasive marker for probing critical aggregate concentration.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Serine Amphiphiles; Histidine Amphiphiles; 1-yne Moiety; Chloroform Gel; Helical Ribbons; Tubules; Multilamellar Spherical Structures
ID Code:21082
Deposited On:20 Nov 2010 09:13
Last Modified:21 Jan 2011 09:50

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