Facile synthesis of novel fluorescent distamycin analogues

Bhattacharya, Santanu ; Thomas, Mini (2001) Facile synthesis of novel fluorescent distamycin analogues Tetrahedron Letters, 42 (32). pp. 5525-5528. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(01)01040-1

Abstract

A facile synthesis of four distamycin analogues that bear the dansyl fluorophore is described. The nature of the linkage between the fluorophore and the sequence recognition element had a dramatic effect on the fluorescence properties of these ligands upon DNA binding. A facile synthesis of four distamycin analogues that bear the dansyl fluorophore is described. The nature of the linkage between the fluorophore and the sequence recognition element had a dramatic effect on the fluorescence properties of these ligands upon DNA binding.

Item Type:Article
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ID Code:21063
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