Bhattacharya, Santanu ; Thomas, Mini (2001) Novel distamycin analogues: facile synthesis of cholesterol conjugates of distamycin-like oligopeptides Tetrahedron Letters, 42 (20). pp. 3499-3502. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/S0040-4039(01)00489-0
Abstract
A facile route towards the synthesis of the first examples of cholesterol-conjugated distamycin analogues is described. These compounds retain their strong binding capacity to double-stranded (ds)-DNA. Aqueous suspensions of these analogues exhibited closed, vesicle-like structures under transmission electron microscope. A facile route toward the synthesis of the first examples of cholesterol conjugates of distamycin is described.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 21056 |
| Deposited On: | 20 Nov 2010 09:17 |
| Last Modified: | 20 Nov 2010 09:17 |
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