Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup

Paul, Bishwajit ; Bajaj, Avinash ; Indi, S. S. ; Bhattacharya, Santanu (2006) Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup Tetrahedron Letters, 47 (47). pp. 8401-8405. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2006.09.072

Abstract

Seven dimeric cationic lipids possessing an aromatic anchor between the hydrocarbon chains and cationic headgroup have been synthesized. The spacers in these lipids vary in length, hydrophobicity and flexibility. The synthesis, membrane-forming properties and complexation with plasmid DNA (lipoplex formation) are briefly described.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Dimeric Lipids; Vesicles; Gene Transfer
ID Code:21040
Deposited On:20 Nov 2010 09:19
Last Modified:21 Jan 2011 06:45

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