Relation between HBsAg binding with polymerized human serum albumin and HBV replication

Irshad, M. ; Gandhi, B. M. ; Acharya, S. K. ; Tandon, B. N. (1987) Relation between HBsAg binding with polymerized human serum albumin and HBV replication Intervirology, 27 (2). pp. 91-94. ISSN 0300-5526

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Official URL: http://content.karger.com/ProdukteDB/produkte.asp?...

Related URL: http://dx.doi.org/10.1159/000149725

Abstract

The binding between hepatitis B surface antigen (HBsAg) and polymerized human serum albumin (poly-HSA) was studied in HBsAg-negative (25) and HBsAg-positive (92) sera by a sensitive enzyme-linked immunosorbent assay technique, and a correlation of binding activity was made with HBe-markers and hepatitis B virus-specific DNA polymerase. The binding could be detected only in HBsAg-positive sera and was found to be independent of the presence of HBe-markers and DNA polymerase activity. Further, binding was noted in significantly higher proportions of sera samples from the patient group compared with the healthy carrier group (p < 0.01).

Item Type:Article
Source:Copyright of this article belongs to Karger Publisher.
Keywords:HBsAg; Polymerized Human Serum Albumin; Hepatitis B Virus; Binding
ID Code:210
Deposited On:17 Sep 2010 09:02
Last Modified:12 May 2011 04:23

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