Genomics of the human Y chromosome and molecular diagnosis

Bashamboo, Anu ; Giran, Harleen Mangat ; Azfer, Md. Asim ; Ali, Sher (2003) Genomics of the human Y chromosome and molecular diagnosis Proceedings of the Indian National Science Academy - Part B: Biological Sciences, B69 (4). pp. 525-538. ISSN 0073-6600

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The human Y chromosome carries a few functional genes as against a plethora of non-coding DNA sequences and shows a high degree of geographical and ethnic variations for a range of loci manifested as genetic polymorphisms. Y-chromosome linked sequence tagged sites (STS) and short tandem repeat (STR) marker systems offer infallible tool for gender identification, paternity testing, genome individualization and assessing male fertility status. Population-specific Y haplotypes and Single Nucleotide Polymorphisms (SNPs) are envisaged to be useful in establishing a correlation between diseased phenotypes with genetic polymorphisms. We discuss genomics of the human Y-chromosome and its possible applications in biology, medical and forensic sciences.

Item Type:Article
Source:Copyright of this article belongs to Indian National Science Academy.
Keywords:Single Nucleotide Polymorphisms (SNPs); Y-linked Marker; Diseased Phenotype; Gender Identification; DNA Diagnosis
ID Code:20801
Deposited On:20 Nov 2010 13:32
Last Modified:17 May 2016 05:04

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