Molecular dissection of the human Y-chromosome

Ali, Sher ; Hasnain, Seyed Ehtesham (2002) Molecular dissection of the human Y-chromosome Gene, 283 (1-2). pp. 1-10. ISSN 0378-1119

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Human Y chromosome, earlier thought to be gene deficient, has attracted a great deal of attention owing to its supremacy in male sex determination and unique haplotype status in the genome. Studies on Y chromosome have shown the presence of different types of satellite DNA and several genes implicated with a variety of physical and physiological functions. The interaction of these repetitive DNA with genes in normal individuals and in patients with Y-chromosome-related genetic anomalies is still an unresolved issue and is actively being pursued. The fast changing scenario of the human genome project is likely to effect our overall understanding of the Y chromosome and Y-linked genetic anomalies in a big way. We provide a brief overview of the organization of Y chromosome with respect to several important loci encompassing both the arms and their likely involvement/modulation in genetic anomalies. The experimental approaches discussed here are envisaged to be of clinical relevance for the molecular diagnosis of the Y-linked disorders.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Minisatellite; Gonadoblastoma; Y-linked Loci; DNA Diagnostics; Turner Syndrome; Mutational Load
ID Code:20691
Deposited On:20 Nov 2010 13:43
Last Modified:17 Feb 2011 11:01

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