Effect of low power microwave on the mouse genome: a direct DNA analysis

Sarkar, Soma ; Ali, Sher ; Behari, J. (1994) Effect of low power microwave on the mouse genome: a direct DNA analysis Mutation Research/Genetic Toxicology, 320 (1-2). pp. 141-147. ISSN 1383-5718

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016512...

Related URL: http://dx.doi.org/10.1016/0165-1218(94)90066-3


The potential mutagenic effect of low power microwave at the DNA sequence level in the mouse genome was evaluated by direct DNA analysis. Animals were exposed to microwave at a power density of 1 mW/cm2 for 2 h/day at a frequency of 2.45 GHz over a period of 120, 150 and 200 days. HinfI digested DNA samples from testis and brain of control and exposed animals were hybridized with a synthetic oligo probe (OAT 36) comprising nine repeats of 5'-GACA-3'. As compared to control animals, band patterns in exposed animals were found to be distinctly altered in the range of 7-8 kb which was also substantiated by densitometric analysis. Though the mechanism of this rearrangement is not yet clear, the results obtained at the present dose are of significance. This dose, which has been set as the safe limit for general public exposure by the Non-Ionizing Radiation Committee of the International Radiation Protection Association, may imply a need for (re)evaluation of the mutagenic potential of microwaves at the prescribed safe limit for the personnel and people who are being exposed.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Microwave; DNA Analysis; Sequence Amplification
ID Code:20682
Deposited On:20 Nov 2010 13:44
Last Modified:04 Jan 2011 11:15

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