Rama Rao, A. V. ; Chakraborty, T. K. ; Laxma Reddy, T. K. (1990) Studies directed towards the synthesis of immunosuppressive agent FK-506: construction of the tricarbonyl moiety Tetrahedron Letters, 31 (10). pp. 1439-1442. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/S0040-4039(00)88827-9
Abstract
Alkylation of a suitably functionalised dithiane precursor with L-N-(-haloacetyl)pipecolic acid methyl ester, followed by oxidation of the active methylene group provided an easy route to 1,2,3-tricarbonyl functionality of FK-506.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 20638 |
| Deposited On: | 20 Nov 2010 13:49 |
| Last Modified: | 20 May 2011 11:39 |
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