A stereospecific synthesis of (4R)-4-[(E)-2-butenyl]-4, N-dimethyl-L-threonine (MeBmt)

Rama Rao, A. V. ; Murali Dhar, T. G. ; Chakraborty, T. K. ; Gurjar, M. K. (1988) A stereospecific synthesis of (4R)-4-[(E)-2-butenyl]-4, N-dimethyl-L-threonine (MeBmt) Tetrahedron Letters, 29 (17). pp. 2069-2072. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(00)87837-5

Abstract

The utility of readily obtainable cis -oxazolidinone derivative (14) has been explored for the efficient and stereospecific synthesis of (4R̲)-4-[(E)-2-butenyl]-4,N-dimethyl-L-threonine, an unusual syn-β-hydroxy-α-amino acid of cyclosporine.

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