Stereoselective synthesis of hydroxyethylene dipeptide isostere from sugar

Chakraborty, T. K. ; Gangakhedkar, K. K. (1996) Stereoselective synthesis of hydroxyethylene dipeptide isostere from sugar Synthetic Communications, 26 (11). pp. 2045-2056. ISSN 0039-7911

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Related URL: http://dx.doi.org/10.1080/00397919608003563

Abstract

Regioselective opening of the aziridine ring in the carbohydrate-based precursor led to the stereoselective synthesis of N-Boc-O-benzyl-(4S,5S)-5-amino-4-hydroxy-6-phenylhexanoic acid methyl ester, the hydroxyethylene dipeptide isostere moiety of potent HIV-1 protease inhibitor.

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