Chakraborty, T. K. ; Ghosh, Subhash ; Ramana Rao, M. H. V. ; Kunwar, A. C. ; Cho, H. ; Ghosh, A. K. (2000) 2,5-anhydro sugar diacid and 2,5-anhydro sugar diamine based C2 symmetric peptidomimetics as potential HIV-1 protease inhibitors Tetrahedron Letters, 41 (51). pp. 10121-10125. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/S0040-4039(00)01803-7
Abstract
Conformationally constrained molecular frameworks of the 2,5-anhydro sugar diacid (9) and 2,5-anhydro sugar diamines (10, 11) were used to construct architecturally beautiful novel C2 symmetric peptidomimetics 1-8. Although none of these compounds showed any significant HIV-1 protease inhibitory activity, further refinements in design may lead to protease inhibitors based on these rigid carbohydrate-derived scaffolds.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 20610 |
| Deposited On: | 20 Nov 2010 13:51 |
| Last Modified: | 22 May 2011 15:51 |
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