Chakraborty, Tushar K. ; Krishna Mohan, B. ; Kiran Kumar, S. ; Kunwar, Ajit C. (2002) Development of 5-(aminomethyl)pyrrole-2-carboxylic acid as a constrained surrogate of Gly-ΔAla and its application in peptidomimetic studies Tetrahedron Letters, 43 (14). pp. 2589-2592. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/S0040-4039(02)00342-8
Abstract
A new peptidomimetic scaffold based on 5-(aminomethyl)pyrrole-2-carboxylic acid (1) is developed for the first time and used as a conformationally constrained surrogate of the Gly-ΔAla dipeptide isostere (2) to prepare peptides 3 and 4.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Peptide Mimetics; Dehydro Amino Acids; Hydrogen Bonding; Conformation; NMR |
| ID Code: | 20598 |
| Deposited On: | 20 Nov 2010 13:54 |
| Last Modified: | 22 May 2011 15:15 |
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