Development of 2,3-diazabicyclo[2.2.1]heptane as a constrained azapeptide template and its uses in peptidomimetic studies

Chakraborty, Tushar K. ; Ghosh, Animesh ; Ravi Sankar, A. ; Kunwar, Ajit C. (2002) Development of 2,3-diazabicyclo[2.2.1]heptane as a constrained azapeptide template and its uses in peptidomimetic studies Tetrahedron Letters, 43 (32). pp. 5551-5554. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(02)01141-3

Abstract

2,3-Diazabicyclo[2.2.1]heptane 1 is used for the first time as a peptidomimetic scaffold in the synthesis of a conformationally constrained analogue 6 of azaproline (or azapipecolic acid) containing peptides.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Peptide Mimetics; Azapeptides; Hydrogen Bonding; Conformation; NMR; Diels-Alder Reactions
ID Code:20594
Deposited On:20 Nov 2010 13:54
Last Modified:22 May 2011 15:14

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