A convenient synthesis of chiral β3-amino acids

Chakraborty, Tushar K. ; Ghosh, Animesh (2002) A convenient synthesis of chiral β3-amino acids Synlett (12). pp. 2039-2040. ISSN 0936-5214

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Official URL: https://www.thieme-connect.com/ejournals/abstract/...

Related URL: http://dx.doi.org/10.1055/s-2002-35608


A novel method for the synthesis of chiral β3-amino acids is developed where the acid functionality was built by oxidative cleavage of an σ-allylic group that was introduced by Evans' asymmetric alkylation of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers Inc.
Keywords:β-amino Acids; Hofmann Rearrangement; Oxazolidinone; Evans' Reaction
ID Code:20593
Deposited On:20 Nov 2010 13:54
Last Modified:22 May 2011 15:45

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