Nucleation of β-hairpin structure in a pyrrole amino acid containing peptide

Chakraborty, Tushar K. ; Krishna Mohan, B. ; Kiran Kumar, S. ; Kunwar, Ajit C. (2003) Nucleation of β-hairpin structure in a pyrrole amino acid containing peptide Tetrahedron Letters, 44 (3). pp. 471-473. ISSN 0040-4039

Full text not available from this repository.

Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(02)02593-5

Abstract

Synthesis and conformational studies of two short peptides containing pyrrole amino acids (1, Paa), Boc-Paa-Paa-d-Pro-Gly-Xaa-Paa-Paa-OMe (2: Xaa = Ala; 3: Xaa = Val), were carried out in which it was established that replacement of Ala in 2 with a Val residue helps peptide 3 to adopt a well-defined β-hairpin conformation in a nonpolar solvent, like CDCl3.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Peptide Mimetics; Pyrrole Amino Acid; Hydrogen Bonding; Conformation; NMR
ID Code:20590
Deposited On:20 Nov 2010 13:54
Last Modified:22 May 2011 15:12

Repository Staff Only: item control page