Chakraborty, Tushar Kanti ; Mohan, Bajjuri Krishna ; Gnanamani, Muthaiah ; Maiti, Souvik (2005) Synthesis and DNA binding properties of pyrrole amino acid-containing peptides Tetrahedron Letters, 46 (4). p. 24. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2004.11.128
Abstract
Dimers of the pyrrole amino acid (Paa), 5-(aminomethyl)pyrrole-2-carboxylic acid, and its derivatives having Lys anchored on N- and C-termini bind in the minor groove of DNA with considerable apparent binding affinities. When the Lys unit is attached to the C-terminus, the resulting ligand binds to ds-DNA with twice the affinity, of the order of 105, than the one carrying two positive charges at the same end.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Pyrrole Amino Acid; DNA Binding; Minor Groove; Distamycin Analogues |
| ID Code: | 20556 |
| Deposited On: | 20 Nov 2010 14:19 |
| Last Modified: | 20 Nov 2010 14:19 |
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