Reddy, Pulimamidi R. ; Mohan, Sepuru K. ; Manjula, Pallerla ; Chakraborty, Tushar K. (2006) A new S4-ligated zinc-peptide 1 : 2 complex for the hydrolytic cleavage of DNA Chemistry and Biodiversity, 3 (4). pp. 456-462. ISSN 1612-1872
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/cbdv.20...
Related URL: http://dx.doi.org/10.1002/cbdv.200690048
Abstract
A new sulfur-ligated Zn-peptide 1 : 2 complex, [ZnII(Boc-NH-Cys-Gly-Cys-OMe)2]2- (2), was prepared, characterized, and tested for its DNA-binding and -cleavage properties. Complex 2 was found to cleave DNA hydrolytically. The negative charge in 2 reduces the affinity of the complex for DNA, and enhances its binding specificity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | DNA; Hydrolytic DNA Cleavage; Zinc Complexes; Kinetics; Peptides |
| ID Code: | 20521 |
| Deposited On: | 20 Nov 2010 14:23 |
| Last Modified: | 22 May 2011 14:57 |
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