Furan based cyclic oligopeptides selectively target G-quadruplex

Chakraborty, Tushar Kanti ; Arora, Amit ; Roy, Saumya ; Kumar, Niti ; Maiti, Souvik (2007) Furan based cyclic oligopeptides selectively target G-quadruplex Journal of Medicinal Chemistry, 50 (23). pp. 5539-5542. ISSN 0022-2623

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jm070619c

Related URL: http://dx.doi.org/10.1021/jm070619c


We report the binding properties of 18- and 24-membered cyclic oligopeptides developed from a novel furan amino acid, 5-(aminomethyl)-2-furancarboxylic acid, to G-quadruplex. Comparative analysis of the binding data of these ligands with G-quadruplex and double-strand DNA shows that 24-membered cyclic peptides are highly selective for telomeric G-quadruplex structures and thus can be used as a scaffold to target quadruplex structures at the genomic level.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:20460
Deposited On:20 Nov 2010 14:29
Last Modified:20 Nov 2010 14:29

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