Total synthesis of hyptolide

Chakraborty, Tushar Kanti ; Purkait, Subhas (2008) Total synthesis of hyptolide Tetrahedron Letters, 49 (38). pp. 5502-5504. ISSN 0040-4039

Full text not available from this repository.

Official URL:

Related URL:


The total synthesis of hyptolide, a naturally occurring α,β-unsaturated six-membered δ-lactone substituted with a polyoxygenated chain, is described. Sharpless kinetic resolution and opening of two different epoxy alcohols under two different conditions-Swern oxidation conditions and a radical reaction using Cp2TiCl-fixed the stereocenters at C-9, C-11, and C-12, respectively. Brown's asymmetric allylation reaction installed the remaining stereocenter at C-6. A RCM protocol was used for construction of the α,β-unsaturated six-membered δ-lactone moiety of the molecule.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Hyptolide; Radical Epoxide Opening; Ring-closing Metathesis
ID Code:20437
Deposited On:20 Nov 2010 14:30
Last Modified:20 Nov 2010 14:30

Repository Staff Only: item control page