A 1 : 2 copper(II)-tripeptide complex for DNA binding and cleavage agent under physiological conditions

Reddy, Pulimamidi R. ; Manjula, Pallerla ; Chakraborty, Tushar K. ; Samanta, Rajarshi (2009) A 1 : 2 copper(II)-tripeptide complex for DNA binding and cleavage agent under physiological conditions Chemistry and Biodiversity, 6 (5). pp. 764-773. ISSN 1612-1872

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/cbdv.20...

Related URL: http://dx.doi.org/10.1002/cbdv.200800079

Abstract

A 1 : 2 copper-tripeptide complex, [CuII(Boc-His-Gly-His-OMe)2]2+, was synthesized and structurally characterized. The absorption band at 577 nm suggests a square-planar geometry around CuII. The DNA-binding and DNA-cleavage properties of the CuII complex were investigated. The complex binds to calf thymus DNA (CT DNA) in an intercalative fashion and cleaves plasmid pUC-19 DNA hydrolytically at micromolar concentrations under physiological conditions. The intrinsic binding constant (Kb = 1.2×102 M-1) for the binding of Cu-tripeptide complex with DNA suggests that this complex is suitable for rapid diffusion on the pharmacological time scale.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Copper Complexes; DNA; Peptides; Kinetics; Intercalation
ID Code:20423
Deposited On:20 Nov 2010 14:31
Last Modified:22 May 2011 14:44

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