Bovine tuberculosis in India: potential basis for zoonosis

Prasad, H. K. ; Singhal, A. ; Mishra, A. ; Shah, N. P. ; Katoch, V. M. ; Thakral, S. S. ; Singh, D. V. ; Chumber, S. ; Bal, S. ; Aggarwal, S. ; Padma, M. V. ; Kumar, S. ; Singh, M. K. ; Acharya, S. K. (2005) Bovine tuberculosis in India: potential basis for zoonosis Tuberculosis, 85 (5). pp. 421-428. ISSN 1472-9792

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Our laboratory has designed a specific nested-PCR (N-PCR) assay, based on the hupB gene of Mycobacterium tuberculosis (Rv2986c) and Mycobacterium bovis (Mb3010c) as a method to differentiate these closely related species. The present paper deciphers the utility of this assay for identification of pathogenic Mycobacteria in clinical samples. Extra-pulmonary clinical samples obtained from cattle and humans were investigated. Pre-dominance of M. tuberculosis (15.7%) and M. bovis (26.8%) was seen in humans and cattle, respectively. However, more importantly, both mycobacterial pathogens (mixed infection) were identified in a number of samples. In humans 8.7% of the samples and 35.7% in cattle were classified as mixed infection. The detection of mixed infection with the mycoabcterial pathogenic duo in humans and bovines denotes the prospect of potential transmission of these pathogens from humans to cattle (zoonosis) and vice versa (reverse zoonosis).

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Zoonotic TB; M. Tuberculosis; M. Bovis; Nested PCR; HupB
ID Code:204
Deposited On:17 Sep 2010 09:02
Last Modified:04 Jun 2011 09:51

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