Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease

Nagesh Babu, G. ; Kumar, Alok ; Chandra, Ramesh ; Puri, S. K. ; Singh, R. L. ; Kalita, Jayantee ; Misra, U. K. (2008) Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease Neurochemistry International, 52 (6). pp. 1284-1289. ISSN 0197-0186

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01970...

Related URL: http://dx.doi.org/10.1016/j.neuint.2008.01.009

Abstract

Free radicals are implicated in numerous disease processes including motor neuron degeneration (MND). Antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G-6-PDH) in the erythrocytes are capable of detoxifying reactive oxygen species produced endogenously or exogenously. In the present study, the extent of lipid peroxidation (LPO) and antioxidant defenses were evaluated in the erythrocytes of 20 sporadic amyotrophic lateral sclerosis (ALS) patients and 20 controls. We observed that lipid peroxidation in the erythrocytes of amyotrophic lateral sclerosis patients significantly increased with respect to controls (P < 0.001). On the other hand, catalase activity was found to be significantly lower (P <0.001). The activities of glucose-6-phosphate dehydrogenase, glutathione reductase and glutathione levels were also found to be significantly reduced in ALS patients compared to healthy subjects (P < 0.001, P < 0.01 and P < 0.01, respectively). It was further observed that lipid peroxidation started to increase and catalase, glutathione reductase, glucose-6-phosphate dehydrogenase enzyme activities and glutathione levels started to decrease as amyotrophic lateral sclerosis progressed from 6 to 24 months, suggesting a correlation between these parameters and duration of amyotrophic lateral sclerosis. This study confirms the involvement of oxidative stress during the progression of amyotrophic lateral sclerosis and the need to develop specific peripheral biomarkers.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Amyotrophic Lateral Sclerosis; Oxidative Stress; Antioxidant Enzymes; Glutathione; Glucose-6-phosphate Dehydrogenase; Lipid Peroxidation
ID Code:19801
Deposited On:22 Nov 2010 11:53
Last Modified:08 Jun 2011 11:35

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