Study of cellular immune response against Hepatitis E Virus (HEV)

Prabhu, S. B. ; Gupta, P. ; Durgapal, H. ; Rath, S. ; Gupta, S. D. ; Acharya, S. K. ; Panda, Subrat Kumar (2010) Study of cellular immune response against Hepatitis E Virus (HEV) Journal of Viral Hepatitis, 18 (8). pp. 587-594. ISSN 1352-0504

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Hepatitis E virus infection (HEV) is a major cause of acute viral hepatitis in the developing world. The immunopathology of HEV infections has not yet been elucidated. The virus is noncytopathic, and therefore, liver injury may be attributed to immune-mediated damage by cytotoxic T cells and natural killer cells. Therefore, we studied the nature of immune cells involved in HEV-induced liver damage using immunohistochemistry in liver biopsies taken from patients with HEV-induced acute liver failure and demonstrated a significant infiltration of activated CD8+ T cells containing granzymes. These findings suggest the possible involvement of cytotoxic T cells in disease pathogenesis during HEV infection.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Acute Liver Failure; Acute Viral Hepatitis; Cytotoxic T Lymphocytes; Immunohistochemistry
ID Code:197
Deposited On:17 Sep 2010 08:54
Last Modified:10 Apr 2012 10:39

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