Protein A - a new ligand for human C-reactive protein

Das, Tanusree ; Mandal, Chhabinath ; Mandal, C. (2004) Protein A - a new ligand for human C-reactive protein FEBS Letters, 576 (1-2). pp. 107-113. ISSN 0014-5793

PDF - Publisher Version

Official URL:

Related URL:


Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an extended definition of CRP. Protein A binding may impart immunomodulatory roles of CRP in combating microorganisms or other foreign materials.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:C-reactive Protein; Glycosylated Human C-reactive Protein; Molecular Variant; Phosphorylcholine; Protein A Binding; Staphylococcus Aureus Cell-surface Protein A
ID Code:19367
Deposited On:22 Nov 2010 12:43
Last Modified:17 May 2016 03:56

Repository Staff Only: item control page