Liposome as an adjuvant for the production of estradiol anti-bodies

Latif, Nahid Ali ; Mandal, Chitra (1987) Liposome as an adjuvant for the production of estradiol anti-bodies Immunology Letters, 15 (3). pp. 237-242. ISSN 0165-2478

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Mice immunized with liposome associated estradiol-bovine serum albumin conjugate (E2-BSA) showed a significantly higher estradiol-specific immune response than did mice injected with the free conjugate. The conjugation of estradiol with BSA is imperative, since injection of liposomes with estradiol in the lipid bilayer was found to be ineffective in inducing an immune response. Entrapment of E2-BSA in neutral and positively charged liposomes was found to be a potent mode of immunostimulation, even better than emulsification in complete Freund's adjuvant (CFA). Covalent liposome surface association of E2-BSA induced a good immunopotentiation. However, the response was lower than that observed with the entrapped conjugate. The affinity and the specificity of antisera, raised in different ways, were determined.

Item Type:Article
Source:Copyright of this article belongs to European Federation of Immunological Societies.
Keywords:Liposome; Adjuvant; Estradiol; Bovine Serum Albumin Conjugate; Antigen Entrapped; Antigen Coupled
ID Code:19310
Deposited On:23 Nov 2010 13:09
Last Modified:28 Feb 2011 10:06

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