Structure of presynaptic toxins: crystallization and preliminary X-ray diffraction data on Notechis II-5, a presynaptic toxin phospholipase

Kannan, K. K. ; Sinh, S. ; Ramanadham, M. ; Eaker, D. (1981) Structure of presynaptic toxins: crystallization and preliminary X-ray diffraction data on Notechis II-5, a presynaptic toxin phospholipase Journal of Biosciences, 3 (1). pp. 29-31. ISSN 0250-5991

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Official URL: http://www.ias.ac.in/jarch/jbiosci/3/29-31.pdf

Related URL: http://dx.doi.org/10.1007/BF02703344

Abstract

The presynaptic neutrotoxin-phospholipase, Notechis II-5 from the venom of NotechisScutatus scutatus (Australian tiger snake) has been crystallized in a form suited for x-ray diffraction analysis. The crystals belong to the orthorhombic space group P21 21,21, with unit cell dimensions, a=146.1, b=43.5 and c=39.0 A. There are two molecules of Notechis II-5 in the asymmetric unit. The molecular weight is about 13,500. Notechis II-5 is highly homologous to Notexin, another presynaptic toxin from the venom of the Australian tiger snake, to bovine and porcine pancreatic phospholipases A and other venom phospholipases.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Notechis II-5; Australian Tiger Snake; Presynaptic Toxin; Crystallization; X-ray Diffraction
ID Code:19111
Deposited On:25 Nov 2010 14:18
Last Modified:17 May 2016 03:44

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