Loeb, L. A. ; Agarwal, S. S. (1971) DNA polymerase correlation with DNA replication during transformation of human lymphocytes Experimental Cell Research, 66 (2). pp. 299-304. ISSN 0014-4827
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001448...
Related URL: http://dx.doi.org/10.1016/0014-4827(71)90681-1
Abstract
The relationship between DNA polymerase activity and DNA replication during lymphocyte transformation has been studied. On the same sample of cells, both thymidine incorporation and polymerase activity were determined. The induction of DNA polymerase precedes the initiation of DNA replication; thereafter, both activities increase proportionately over a 30-fold range. The deoxynucleotide composition of DNA synthesized in vitro by homogenates of stimulated lymphocytes is similar to that of the added DNA template. The accuracy of dAT copolymer replication is such that equal amounts of dATP and dTTP are incorporated, while if any dCTP or dGTP is incorporated it occurs at a frequency of less than 1 in 103.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 19 |
| Deposited On: | 16 Sep 2010 08:31 |
| Last Modified: | 12 May 2011 04:18 |
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