Antipyrine kinetics in undernourished diabetics

Shobha, J. C. ; Raghuram, T. C. ; Deva Kumar, A. ; Krishnaswamy, K. (1991) Antipyrine kinetics in undernourished diabetics European Journal of Clinical Pharmacology, 41 (4). pp. 359-361. ISSN 0031-6970

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In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and their plasma glucose values were within normal limits. The AUC of antipyrine was similar in all the groups. Although none of the kinetic parameters was altered in normal diabetics, the clearance of antipyrine was decreased and its half life was prolonged, with an increase in volume of distribution, in undernourished diabetics compared to undernourished controls. The results indicate that diabetes per se may not influence antipyrine kinetics when the blood glucose is well under control, but in the presence of undernutrition, it significantly alters the disposition of the drug.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Diabetes; Antipyrine; Undernutrition; Drug Metabolism; Pharmacokinetics
ID Code:18716
Deposited On:17 Nov 2010 12:32
Last Modified:04 Jun 2011 08:59

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