Raghuram, T. C. ; Krishnaswamy, Kamala ; Rao, K. V. Krishna (1982) Influence of dietary restriction and protein deficiency on plasma half-life and tissue distribution of tetracycline in rats Clinical and Experimental Pharmacology and Physiology, 9 (2). pp. 139-144. ISSN 0305-1870
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1440-...
Related URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00790.x
Abstract
The effects of dietary restriction and protein deficiency on plasma half-life and tissue distribution of tetracycline were studied in rats by feeding either a 20% protein diet in restricted quantity or a 9% protein diet ad lib and compared with rats given a 20% protein diet ad lib (control group). 1 It was observed that half-life of tetracycline was shortened and that plasma and tissue Cmin levels at steady-state were lower in undernourished rats. Tissue concentrations in liver, kidney, muscle and bone correlated well with plasma levels. A high degree of correlation was also observed between plasma and tonsillar concentrations of tetracycline in human subjects. 2 These studies indicate that undernourished subjects may require an altered dosage regimen of tetracycline to maintain effective steady-state concentrations of the drug.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | Half-life; Malnutrition; Tetracycline; Tissue-distribution |
| ID Code: | 18714 |
| Deposited On: | 17 Nov 2010 12:32 |
| Last Modified: | 24 Feb 2011 04:07 |
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