Effect of Brassica nigra on Benzo[a]pyrene mutagenicity

Polasa, K. ; Kumar, P. U. ; Krishnaswamy, K. (1994) Effect of Brassica nigra on Benzo[a]pyrene mutagenicity Food and Chemical Toxicology, 32 (8). pp. 777-781. ISSN 0278-6915

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S02786...

Related URL: http://dx.doi.org/10.1016/S0278-6915(09)80011-2

Abstract

Male rats were given diets containing Brassica nigra (mustard seed) powder at 0, 1, 5 or 10% for 1 month and then exposed to benzo[o]pyrene (B[a]P. 1 mg by ip injection). The antimutagenic effect due to mustard was assessed by testing the urine of rats fed diets with and without mustard. There was a significant (P < 0.001) reduction in reversion frequency of the TA98 and TA100 strains of Salmonella typhimurium in mustard-fed groups. This protective effect was seen with all three doses of mustard. The study demonstrated that mustard (Brassica nigra) can be a potent antagonist of the adverse biological effects of the ultimate metabolites of B[a]P, a ubiquitous environmental genotoxicant.

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