Serotonin metabolism in pellagra

Raghuram, Thummala C. ; Krishnaswamy, Kamala (1975) Serotonin metabolism in pellagra Archives of Neurology, 32 (10). pp. 708-710. ISSN 0003-9942

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Altered mental status is common in pellagrins. We evaluated the mental status of pellagrins in relation to the neurohormone, serotonin or 5-hydroxytryptamine (5-HT). Levels of 5-hydroxyindoleacetic acid (5-HIAA), an end product of serotonin in the urine and cerebrospinal fluid (CSF), and of platelet 5-HT were determined in a group of pellagrins and in normal subjects. The results indicated that the 5-HT concentration was reduced in platelets and 5-HIAA excretion in urine was below normal levels. The 5-HIAA concentration in CSF was also reduced, suggesting a decrease in 5-HT functional activity in the brain.

Item Type:Article
Source:Copyright of this article belongs to American Medical Association.
ID Code:18678
Deposited On:17 Nov 2010 12:35
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