Effect of food on bioavailability of rifampicin

Polasa, K. ; Krishnaswamy, K. (1983) Effect of food on bioavailability of rifampicin Journal of Clinical Pharmacology, 23 (10). pp. 433-437. ISSN 0091-2700

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Official URL: http://jcp.sagepub.com/content/23/10/433.abstract


The area under the plasma concentration-time curve of rifampicin was determined with and without food administration in six healthy male volunteers. Rifampicin (10 mg/kg) was administered orally in the fasting state on one occasion and following a wheat-based breakfast on another. Administration of rifampicin with food reduced mean peak plasma concentration and prolonged the time to reach peak concentration (2 versus 4 hours). Total area under the concentration-time curve from 0 to 8 hours and the rate of absorption were also significantly reduced when rifampicin was administered with food.

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