Effect of food on bioavailability of chloroquine

Tulpule, A. ; Krishnaswamy, K. (1982) Effect of food on bioavailability of chloroquine European Journal of Clinical Pharmacology, 23 (3). pp. 271-273. ISSN 0031-6970

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Official URL: http://www.springerlink.com/content/j86pg60370r561...

Related URL: http://dx.doi.org/10.1007/BF00547567


The bioavailability of chloroquine in 7 healthy adult male volunteers was assessed with and without a standard breakfast. Chloroquine (600 mg base) was administered orally and timed blood samples were obtained for determination of plasma concentrations. The results suggest that the AUC and peak plasma levels were significantly higher when chloroquine was administered together with food, although the rate of absorption was not different. It appears, therefore, that food facilitates chloroquine absorption and the extent of absorption is significantly modified. Hence administration of chloroquine together with food appears to be an advisable clinical practice.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Chloroquine; Bioavailability; Gastrointestinal Absorption; Food Effect
ID Code:18662
Deposited On:17 Nov 2010 12:37
Last Modified:04 Jun 2011 09:05

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