Circumvention of multidrug resistance in neoplastic cells through scavenger receptor mediated drug delivery

Mukhopadhyay, Amitabha ; Mukhopadhyay, Bratati ; Basu, S. K. (1995) Circumvention of multidrug resistance in neoplastic cells through scavenger receptor mediated drug delivery FEBS Letters, 376 (1-2). pp. 95-98. ISSN 0014-5793

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...

Related URL: http://dx.doi.org/10.1016/0014-5793(95)01250-6

Abstract

A conjugate of the antineoplastic drug daunomycin (DNM) with maleylated bovine serum albumin (MBSA-DNM) was taken up with high efficiency by a multidrug resistant variant, JD100, of the murine-macrophage tumour cell line, J774A.1, through the scavenger receptors resulting in cessation of DNA synthesis. In contrast, free DNM at similar concentrations did not affect the incorporation of [3H]thymidine by these cells. These results suggest that receptor-mediated intracellular delivery of antineoplastic drugs could be a viable and new approach for overcoming the problem of multidrug resistance in chemotherapy of neoplastic diseases.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:Multidrug Resistance; Scavenger Receptor; Endocytosis; Drug Targeting
ID Code:1837
Deposited On:08 Oct 2010 12:00
Last Modified:16 May 2016 12:53

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