A geochemical basis for endomyocardial fibrosis

Valiathan, M. S. ; Kartha, C. C. ; Panday, V. K. ; Dang, H. S. ; Sunta, C. M. (1986) A geochemical basis for endomyocardial fibrosis Cardiovascular Research, 20 (9). pp. 679-682. ISSN 0008-6363

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Official URL: http://cardiovascres.oxfordjournals.org/content/20...

Related URL: http://dx.doi.org/10.1093/cvr/20.9.679


In a search for geochemical factors that could play a role in the pathogenesis of tropical endomyocardial fibrosis, endomyocardial tissue samples obtained from patients at necropsy or operation were analysed for major elements present in laterite and monazite, which are important soil constituents of Kerala State of India. Atomic absorption spectrophotometry was used for detecting iron, silicon, aluminium, zinc, magnesium, calcium, sodium, potassium, and manganese and neutron activation analysis for thorium. Compared with control samples from victims of fatal accidents, an excess of thorium, sodium, and calcium and a deficiency of magnesium were present in samples from patients. It has been shown earlier that the staple diets of people in Kerala have high concentrations of thorium, and these data show that thorium can become concentrated in cardiac tissues. It is speculated that thorium excess in conjunction with magnesium deficiency may play a role in the causation of tropical endomyocardial fibrosis.

Item Type:Article
Source:Copyright of this article belongs to European Society of Cardiology.
Keywords:Thorium; Magnesium; Atomic Absorption Spectrophotometry
ID Code:18149
Deposited On:17 Nov 2010 13:05
Last Modified:03 Jul 2012 05:47

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