Biswas, S. ; Singh, V. K. ; Rastogi, A. ; Sharan, R. ; Haq, W. ; Mathur, K. B. ; Agarwal, S. S. (1997) Stimulation of IL-2 production and CD2R expression by splenopentin analogs International Journal of Immunopharmacology, 19 (6). pp. 341-345. ISSN 0192-0561
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01920...
Related URL: http://dx.doi.org/10.1016/S0192-0561(97)00032-5
Abstract
Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin. Its synthetic analogs: Lys-Lys-Glu-Val-Tyr (1) and D-Lys-Lys-Glu-Val-Tyr (2) have been evaluated for active T-cell rosette (CD2R), total T-cell rosette (CD2), interleukin-2 (IL-2) stimulation and effect on antibody production. SP-5 as well as both the analogs stimulated CD2R. Analogs (1) and (2) were also found to stimulate IL-2 production. These observations suggest that in vitro human NK cell augmentation with analogs (1) and (2) reported earlier may be due to enhanced IL-2 production.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | CD2R; Immunomodulators; Interleukin-2; Splenopentin |
| ID Code: | 180 |
| Deposited On: | 17 Sep 2010 08:50 |
| Last Modified: | 12 May 2011 03:48 |
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