Bhattacharya, Basabi ; Mandal, Chhabinath ; Basu, Sandip ; Sarkar, Pranab Kumar (1987) Regulation of α- and β-tubulin mRNAs in rat brain during synaptogenesis Molecular Brain Research, 2 (2). pp. 159-162. ISSN 0169-328X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016932...
Related URL: http://dx.doi.org/10.1016/0169-328X(87)90009-X
Abstract
Developmental alterations in α- and β-tubulin mRNA in polysomes from brains of -3 days (fetal) to 30-day-old rats were quantitated by using well-characterized chicken α- and β-tubulin cDNA probes, pT1 and pT2 having 80-90% homology with rat sequences. Northern blot analysis revealed a single major (> 95%) 1.8 kb mRNA for both α- and β-tubulin. Quantitation by slot hybridization indicates a virtually coordinate expression of α- and β-tubulin mRNA with a maximal level around day 5 after birth, which represents the mid-phase of synaptogenesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Tubulin mRNA; Synaptogenesis; Brain Development; Neurotubule; Gene Expression |
| ID Code: | 1799 |
| Deposited On: | 08 Oct 2010 12:28 |
| Last Modified: | 16 May 2012 14:28 |
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