Synthesis of highly strained enediynes and dienediynes

Basak, Amit ; Roy , Sandip K. ; Basab, Roy ; Ajoy, Basak (2008) Synthesis of highly strained enediynes and dienediynes Current Topics in Medicinal Chemistry, 8 (6). pp. 487-504. ISSN 1568-0266

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Official URL: http://www.bentham.org/ctmc/contabs/ctmc8-6.htm#6

Related URL: http://dx.doi.org/10.2174/156802608783955728

Abstract

Enediynes continue to fascinate scientists working in various domains because of their structural complexity and fascinating biological mode of action. They represent a masterpiece of nature's ingenuity. Besides the warhead which is the enediyne moiety, these molecules are equipped with a locking device, a delivery system and a chemical trigger for activation. Upon triggering, the molecules become active and undergo a thermal rearrangement that was disclosed in the early 70 by Masamune and Bergman and commonly known as Bergman cyclization. The reaction is believed to precede through a diradical benzenoid species (a p-benzyne). This review describes the various strategies employed for the synthesis of highly strained enediynes and dienediynes, both naturally occurring and the designed ones.

Item Type:Article
Source:Copyright of this article belongs to Bentham Science Publishers Ltd.
ID Code:1786
Deposited On:05 Oct 2010 12:01
Last Modified:13 Jan 2011 07:00

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