Synthesis of isoxazoline-fused bicyclic enediynes via intramolecular nitrile oxide-alkene cycloaddition

Basak, Amit ; Pal, Runa (2008) Synthesis of isoxazoline-fused bicyclic enediynes via intramolecular nitrile oxide-alkene cycloaddition Synlett, 2008 (14). pp. 2115-2118. ISSN 0936-5214

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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...

Related URL: http://dx.doi.org/10.1055/s-2008-1078244

Abstract

The intramolecular nitrile oxide-alkene cycloaddition has been studied in an enediyne system. It has been shown to be an efficient method for one-step synthesis of isoxazoline-fused bicyclic enediynes. The thermal reactivity of these enediynes is similar to the isoxazolidine-fused counterparts, thus ruling out any significant effect by the bridgehead double bond.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers Inc.
Keywords:Enediyne; Cycloaddition; Bergman Cyclization; Intra­molecular; Activation
ID Code:1785
Deposited On:05 Oct 2010 12:01
Last Modified:05 Oct 2010 12:01

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