Synthesis and reactivity of cyclam-based enediynes

Kara, Moumita ; Basak, Amit ; Bhattacharjee, Manish (2006) Synthesis and reactivity of cyclam-based enediynes Tetrahedron Letters, 47 (1). pp. 117-120. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.10.125

Abstract

Cyclam-based enediynes 1-3 have been synthesized for the first time either by direct bis- or tetra-alkylation of the cyclam or via double alkylation of the 1,8-bis-sulfonyl derivative. The enediyne 1 readily forms a complex with Ni(II), which also lowered the onset temperature for Bergman cyclization of the parent enediyne by 60°C. In the presence of a co-oxidant, MMPP, the Ni-complex can cleave ds-DNA into the nicked relaxed form at micromolar concentrations.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Cyclam; Enediyne; Calorimetry; Cyclization; Cleavage
ID Code:1754
Deposited On:05 Oct 2010 11:13
Last Modified:13 Jan 2011 09:44

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