Basak, Amit ; Kar, Moumita ; Mandal, Subrata (2005) Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design Bioorganic & Medicinal Chemistry Letters, 15 (8). pp. 2061-2064. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2005.02.051
Abstract
A novel pyridine diamine-based cyclic enediyne 1 was synthesized by bis-N-alkylation of 2,6-bis-sulfonamido pyridine 6 followed by deprotection with thiophenol. A variety of salts 1a-c of the parent amine 1 were prepared. Thermal reactivity studies indicated a dependence of the reactivity upon the extent of salt formation. This observation may be useful in pH-based design of enediynes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Enediyne; Bergman Cyclization; Calorimetry; Drug; Design |
| ID Code: | 1750 |
| Deposited On: | 05 Oct 2010 11:14 |
| Last Modified: | 13 Jan 2011 10:03 |
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