Chlorinated hydrocarbons: estrogens and antiestrogens

Safe, S. ; Krishnan, V. (1995) Chlorinated hydrocarbons: estrogens and antiestrogens Toxicology Letters, 82-83 . pp. 731-736. ISSN 0378-4274

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds bind to the intracellular aryl hydrocarbon (Ah) receptor and induce a diverse spectrum of biochemical and toxic responses. Ah receptor agonists also modulate several endocrine pathways, and research in several laboratories has shown that TCDD and related compounds inhibit estrogen (E2)-induced responses in the rodent mammary and uterus and in human breast cancer cell lines. The mechanisms of interaction between the TCDD- and E2-induced signaling pathways are complex and some of the inhibitory effects may be related to 5'-flanking inhibitory-dioxin responsive elements (i-DREs) in target genes. The antiestrogenic and antitumorigenic activity of Ah receptor agonists has been used to prepare a series of relatively non-toxic alkyl polychlorinated dibenzofurans which have clinical potential for treatment of mammary cancer.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:TCDD; Ah Receptor; Antiestrogenicity
ID Code:17278
Deposited On:16 Nov 2010 08:04
Last Modified:04 Jun 2011 06:27

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