Dasgupta, D. ; Thanabal, V. ; Krishnan, V. (1982) Metallo crown porphyrins as ionophores-metal dependent uncoupling of mitochondrial energy potential Biochemical and Biophysical Research Communications, 104 (4). pp. 1427-1433. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(82)91409-7
Abstract
Porphyrins appended with crown ether moieties function as efficient uncouplesrs of oxidative phorphorylation in rat liver mitochondria. Permeation of these highly organized porphyrins decrease the respiratory coefficient index (RCI) values. Lowering of the RCI values parallels the number of K+ chelating crown ether groups attached to the porphyrins. The inhibitory effect upon the oxidative phorphorylation reaction depends on the nature of divalent metal ions, VO, Co, Cu and Zn in the porphyrin cavity and related to their relative tendency to complex intracellular K+ ions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 17251 |
| Deposited On: | 16 Nov 2010 08:07 |
| Last Modified: | 04 Jun 2011 06:48 |
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