Blends of reverse enteric polymer with enteric and pH-independent polymers: mechanistic investigations for tailoring drug release

Menjoge, Anupa R. ; Kulkarni, Mohan G. (2007) Blends of reverse enteric polymer with enteric and pH-independent polymers: mechanistic investigations for tailoring drug release Biomacromolecules, 8 (1). pp. 240-251. ISSN 1525-7797

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Official URL: http://pubs.acs.org/doi/abs/10.1021/bm060540%2B

Related URL: http://dx.doi.org/10.1021/bm060540+

Abstract

Blends of conventional reverse enteric polymer with enteric polymers result in insoluble polyelectrolyte complexes and hence cannot be used in film coatings. We report a new set of miscible blends of a new reverse enteric polymer (NREP) synthesized by us with enteric and pH-independent polymers. The nature of interactions between polymers in the blends has been established by analyzing Fourier transform infrared (FTIR) spectra. The extent of interaction has been investigated by thermal analysis and quantified in terms of parameters K1 and K2 in the Schneider equation. Based on these values, the interactions between NREP and these polymers have been ranked in the order EC (ethylcellulose) < ES (Eudragit S) < HPMCP (hydroxypropyl methylcellulose phthalate). The quantification of interactions in blends helps explain the release pattern of cefuroxime axetil (CA) at gastric pH and tailor the release of other drugs according to their pharmacokinetic characteristics. The understanding also provides a more rational approach for selection of polymers and their content in the coating compositions, rather than an empirical approach.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:17126
Deposited On:16 Nov 2010 08:25
Last Modified:04 Jun 2011 08:10

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