Vyavahare, N. R. ; Kulkarni, M. G. ; Mashelkar, R. A. (1990) Zero order release from swollen hydrogels Journal of Membrane Science, 54 (1-2). pp. 221-228. ISSN 0376-7388
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S03767...
Related URL: http://dx.doi.org/10.1016/S0376-7388(00)82081-5
In vitro release studies of theophylline from a series of swollen poly (2-hydroxyethyl methacrylate-co-glycidyl methacrylate), p (HEMA-GMA), hydrogels in water and in 0.05 N sulphuric acid are reported. Release in water follows the conventional Higuchi relationship. In acidic medium, the release index is found to vary between 0.7 and 0.9. The results are attributed to the structural changes taking place in the matrix during the course of release in acidic medium.
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|Deposited On:||16 Nov 2010 13:59|
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