Zero order release from swollen hydrogels

Vyavahare, N. R. ; Kulkarni, M. G. ; Mashelkar, R. A. (1990) Zero order release from swollen hydrogels Journal of Membrane Science, 54 (1-2). pp. 221-228. ISSN 0376-7388

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In vitro release studies of theophylline from a series of swollen poly (2-hydroxyethyl methacrylate-co-glycidyl methacrylate), p (HEMA-GMA), hydrogels in water and in 0.05 N sulphuric acid are reported. Release in water follows the conventional Higuchi relationship. In acidic medium, the release index is found to vary between 0.7 and 0.9. The results are attributed to the structural changes taking place in the matrix during the course of release in acidic medium.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:17109
Deposited On:16 Nov 2010 08:29
Last Modified:04 Jun 2011 08:30

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