Basak, Amit ; Pal, Runa (2005) Synthesis of β-lactam nucleoside chimera via Kinugasa reaction and evaluation of their antibacterial activity Bioorganic & Medicinal Chemistry Letters, 15 (8). pp. 2015-2018. ISSN 0960-894X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2005.02.064
Abstract
Several β-lactam nucleoside chimeras 1 (cis) and 2 (trans) were synthesized from the corresponding N-propargyl nucleobases via Kinugasa reaction in moderate yields. Initial screening for antibacterial activity against ampicillin sensitive E. coli showed weak activity for the uracil-β-lactam chimera.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 1707 |
| Deposited On: | 05 Oct 2010 12:06 |
| Last Modified: | 05 Oct 2010 12:06 |
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