Differential effects of stereochemistry and C-4 substituents on the enantioselectivity of PLE and PPL catalyzed hydrolysis of 3,4-disubstituted β-lactams

Basak, Amit ; Mahato, Tapan ; Bhattacharya, Gautam ; Mukherjee, Ballari (1997) Differential effects of stereochemistry and C-4 substituents on the enantioselectivity of PLE and PPL catalyzed hydrolysis of 3,4-disubstituted β-lactams Tetrahedron Letters, 38 (4). pp. 643-646. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4039(96)02381-7

Abstract

Pig liver Esterase (PLE) and Pig Pancreas Lipase (PPL) catalysed hydrolysis of (± ) trans-3-carbethoxy and (± ) cis-3-acetoxymethyl 4-substituted β-lactams revealed interesting dependence on C-3, C-4 stereochemistry and nature of C-4 substituents.

Item Type:Article
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Deposited On:05 Oct 2010 12:06
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