Nageshwar Rao, I. ; Prabhakaran, E. N. ; Das, Saibal Kumar ; Iqbal, Javed (2003) Cobalt-catalyzed one-pot three-component coupling route to β-acetamido carbonyl compounds: a general synthetic protocol for γ-lactams Journal of Organic Chemistry, 68 (10). pp. 4079-4082. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo020559c
Related URL: http://dx.doi.org/10.1021/jo020559c
Abstract
An efficient improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of γ-lactams by a three-component coupling reaction with use of 2-carbomethoxybenzaldehyde. The β-acetamido carbonyl compounds derived from 2-carbomethoxybenzaldehyde are useful intermediates as they can be transformed to the corresponding γ -lactams on treatment with base.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 16969 |
| Deposited On: | 16 Nov 2010 13:14 |
| Last Modified: | 17 Feb 2011 04:45 |
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