Balraju, V. ; Srinivasa Reddy, D. ; Periasamy, Mariappan ; Iqbal, Javed (2005) Synthesis of conformationally constrained cyclic peptides using an intramolecular sonogashira coupling Journal of Organic Chemistry, 70 (23). pp. 9626-9628. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo051412z
Related URL: http://dx.doi.org/10.1021/jo051412z
Abstract
Small peptides having a 3-bromobenzyl group at the C-termini and n-alkynoyl group at the N-termini undergo a smooth copper-free intramolecular Sonogashira coupling reaction to afford the corresponding cyclic peptides in moderate yields. Scope and limitations of this macrocyclization is demonstrated with di-, tri-, and tetrapeptides.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 16954 |
| Deposited On: | 16 Nov 2010 13:15 |
| Last Modified: | 22 Feb 2011 09:52 |
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